Big Man On Campus

I apologize for allowing this little private school to assume the atmosphere of a research university lately. Daniel Webster is still remembered in this quarter. My career frustration was strangely prescient, though, as to the potential impact of lamellar reorganization theory. What did I say, "...cancer, heart disease, diabetes, and drug addiction"? Here are a few concluding thoughts, just in case anyone with real educational credentials happens to blow through here. In case Google screws up, in other words. ;-)

After applying the deliberate, deep toner followed by moisturizer to persistent lesions on my face in the afternoon, I dabbed my vitamin D shaving oil at night, and I felt it. Like the first time I put supplement on the lesions that DID respond. Fibroblasts are little connective tissue cells that repair injury. Recently, they have been caught on video recruiting tumor cells, and probably telling them not to die. You know it's mostly old people who get cancer, and that's probably because the properly functioning, non-rogue fibroblasts are programmed to retire. Scientists are working on that, too, for good or ill. But I think the D3 gives a competing hormonal signal directly to the tumor cells, telling them to die. Which is a good thing not only in the case of cancer, but in the case of benign lesions in the shaving area.

I've read (sorry for no references, here, G+ isn't very searchable) that cancer patients experience intensely uncomfortable, generalized water retention in chemotherapy. What I don't know anyone understands at this point, is that that is probably why it works. Tumor cells normally use "antioxidants" for inappropriate self-defense against signals that they should die. But if they have to burn them up in acute tissue reorganization, they would then be more susceptible to those signals.

In heart disease, desmosomes already get a lot of attention, as they are part of complex junctions that define the special function of that tissue. In cardiomyopathy, the fibroblasts replace that function with nonfunctional cartilage. (My dad has a lot of this, after a first heart attack at age 30 and several subsequent bypass surgeries.) Everyone is focused on the blood-thinning, but isn't it obvious that aspirin could facilitiate more functional repairs of the cardiac muscle itself?

That's all I've got for now... diabetes and drug addiction involve highly complicating appetitive systems. Turn that on its head, though, and the co-morbidity of the major causes of death suggests related nutritional deficits. Though the body cannot always be satisfied, the brain is so flexible that it usually can be, despite everything. It's like the "rogue fibroblast" at large.